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首页>> 名师风采 >> 中心研修导师>>
 
吴立玲(基础医学院)
发布日期:2017-04-19 浏览次数: 5 字号:[ ]

  • 学历背景

1973.91977.1  南京铁道医学院医学系      本科生

1978.91981.4  北京医学院病理生理学专业  硕士研究生

 

  • 专业及科研方向

从事病理生理学教学与科研工作,主要研究心血管疾病的发病机制以及唾液腺分泌的调控

 

  • 教学经历(包括主讲课程、获教学奖项等):

主讲研究生和本科生的病理生理学课程,是国家级精品资源共享课(病理生理学)的负责人,获得北京市教学名师称号,主编的病理生理学教材被评为“十五”、“十一五”和“十二五”教育部规划教材,3次被评为北京高等教育精品教材。

 

  • 教学感悟:

用心去做,启发为先,师生交流,共同提高

 

 

附:

  • 参与课题

1)教学课题

2010年教育部“国内外高等教育教材比较研究”

2014年北医“病理生理学考试改革与创新型人才培养模式的构建”

2)科研课题

先后承担9项国家自然科学基金课题,3项教育部博士点课题和一项北京市自然科学基金课题。

 

  • 发表文章

1)教学文章

1) 李丽, 王程, 向若兰, 窦豆, 王瑾瑜, 张艳, 刘俊昌, 徐海, 吴立玲. 以病例讨论为主导的教学新模式在病理生理学教学中的应用. 中华医学教育杂志2010; 30(6):876-878.

2)王程, 吴立玲. 中美病理生理学教材的比较分析.中华医学教育杂志2011; 31:315-317

3) 窦豆,徐海,杨吉春,高远生,吴立玲. 情境式命题在病理生理学考试改革中的作用分析. 中华医学教育杂志. 2015, 35(6):942-945.

4) 刘利梅,徐海,程化琴,向若兰,窦豆,李丽,王瑾瑜,张艳,高远生,吴立玲. “以学生为本理念下的《病理生理学》考试改革的实践探索. 基础医学与临床. 2016, 36(8):1168-1171.

2)科研文章

1.       Li L, Wu LL, Wang C, Liu LM, Zhao YL. Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes. Regulatory Peptides 2007; 139:72–79.

2.       Wang C,Wu LL, Liu J, Zhang ZG, Fan D, Li L. The crosstalk between angiotensin II- and platelet-derived growth factor-BB mediated signal pathways in cardiomyocytes. Chin Med J 2008; 121(3):236-240

3.       Xiang B, Zhang Y, Li YM, Gao Y, Gan YH, Wu LL, Yu GY. Phenylephrine protects autotransplanted rabbit submandibular gland from apoptosis. Biochem Biophys Res Commun 2008; 377:210–214.

4.       Li YM, Zhang Y, Shi L,. Xiang B, Cong X, Zhang YY, Wu LL, Yu GY.Isoproterenol improves secretion of transplanted submandibular gland. J Dent Res 2009; 88(5):477-482.

5.       Wang C, Li L, Zhang ZG, Fan D, Zhu Y, Wu LL. Globular adiponectin inhibits angiotensinII-induced nuclear factor κB activation through AMP-activated protein kinase in cardiac hypertrophy. J Cell Physiol, 2010; 222: 149–155.

6.       L Shi, X Cong, Y Zhang, C Ding, QW Ding, FY Fu, LL Wu, GY Yu. Carbachol improves secretion in the early phase after rabbit submandibular gland transplantation. Oral Diseases, 2010; 16:351–359.

7.       Li L, Zhou Y, Wang C, Zhao YL, Zhang ZG, Fan D, Cui XB, Wu LL. Src tyrosine kinase regulates angiotensin II-induced protein kinase Cζ activation and proliferation in vascular smooth muscle cells. Peptides, 2010; 31:1159–1164.

8.       Ding QW, Zhang Y, Wang Y, Wang YN, Zhang L, Ding C, Wu LL, Yu GY. Functional vanilloid receptor-1 in human submandibular glands. J Dent Res, 2010; 89(7):711-716.

9.       Zhang Y, Cong X, Shi L, Xiang B, Li YM, Ding QW, Ding C, Wu LL, Yu GY. Activation of transient receptor potential vanilloid subtype 1 increases secretion of the hypofunctional, transplanted submandibular gland. Am J Physiol Gastrointest Liver Physiol, 2010; 299:G54–G62.

10.  Li BB, Chen ZB, Li BC, Lin Q, Li XX, Li SL, Ding C, Wu LL, Yu GY. Expression of ghrelin in human salivary glands and its levels in saliva and serum in Chinese obese children and adolescents. Arch Oral Biol. 2011; 56(4): 389-394.

11.  Fan D, Li L, Wang C, Cui XB, Zhou Y, Wu LL. Adiponectin induces interleukin-6 production and its underlying mechanism in adult Rat cardiac fibroblasts. J Cell Physiol, 2011; 226(7):1793-1802.

12.  Li L, Fan D, Wang C, Wang JY, Cui XB, Wu D, Zhou Y, Wu LL. Angiotensin II increases periostin expression via Ras/p38MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. Cardiovasc Res 2011; 91:80-89.

13.  Ding C, Zhang Y, Peng Xin, Wang Y, Zhang L, Cong X, Ding QW, Xiang RL, Wu LL, Yu GY. Proteomic analysis of human transplanted submandibular gland in patients with epiphora after transplantation. J Proteome Res2011; 10(5):2206-2215.

14.  Ding QW, Zhang Y, Cong X, Cai ZG, Han JY, Su YC, Wu LL, Yu GY. Confocal microscopy with double immunofluorescence staining reveals the functional transient receptor potential vanilloid subtype 1 expressed in myoepithelial cells of human submandibular glands. Microsc Res Techniq 2012; 75(5):555-560.

15.  Cui XB, Wang C, Li L, Fan D, Zhou Y, Wu D, Cui QH, Fu FY, Wu LL. Insulin decreases myocardial adiponectin receptor 1 expression via PI3K/Akt and FoxO1 pathway. Cardiovasc Res 2012; 93:69-78.

16.  Cong X, Zhang Y, Shi L, Yang NY, Ding C, Ding QW, Su YC, Xiang RL, Wu LL, Yu GY. Activation of transient receptor potential vanilloid subtype 1 (TRPV1) increases expression and permeability of tight junction in normal and hyposecretory submandibular gland. Lab Invest 2012; 92(5):753-768.

17.  Song B, Zhang L, Liu XJ, Ding C, Wu LL, Gan YH, Yu GY. Proteomic analysis of secretion from human transplanted submandibular gland replacing lacrimal gland with severe keratoconjunctivitis sicca. BBA-Proteins and Proteomics 2012, 1824(4):550-560.

18.  Yang NY, Shi L, Zhang Y, Ding C, Cong X, Fu FY, Wu LL, Yu GY. Ischemic preconditioning reduces the transplanted submandibular gland injury. J Surg Res. 2013; 179:E265-E273.

19.  Guo XH, Wang JY, Gao Y, Gao M, Yu GY, Xiang RL, Li L, Yang NY, Cong X, Xu XY, Li SL, Peng X, Wu LL. Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma. Cancer Sci 2013; 104(2):206-213.

20.  Li L, Zhang ZG, Lei H, Wang C, Wu LP, Wang JY, Fu FY, Zhu WG, Wu LL. Angiotensin II reduces cardiacAdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway. PLoS One 2013; 8(1):e49915

21.  Xin C, Zhang Y, Yang NY, Li J, Ding C, Ding QW, Su YC, Mei M, Guo XH, Wu LL, Yu GY. Occludin is required for transient receptor potential vanilloid subtype 1-modulated paracellular permeability in submandibular gland. J Cell Sci 2013 126:1109–1121.

22.  Ding C, Li L, Su YC, Xiang RL, Cong X, Yu HK, Li SL, Wu,LL,Yu GY. Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling. PLoS One 2013; 8(5):e63878.

23.  Ding C, Cong X, Zhang Y, Yang NY, Li SL, Wu LL, Yu GY. Hypersensitive mAChRs are involved in the epiphora of transplanted glands. J Dent Res2014; 93(3):306-312.

24.  Zhou Y, Wang JY, Feng H, Wang C, Li L, Wu D, Lei H, Li Hao, Wu LL. Overexpression of C1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro. Arterioscler Thromb Vasc Biol. 2014; 34:1002-1010.

25.  Su YC, Xiang RL, Zhang Y, Ding C, Cong X, Guo XH, Yang NY, Hua H, Wu LL, Yu GY. Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in NOD mice.Oral Diseases 2014; 20:744-755.

26.  Xiang RL, Mei M, Cong X, Li J, Zhang Y, Ding C, Wu LL, Yu GY. Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells. J Mol Cell Biol 2014; 6(6):486–497.

27.  Su JZ, Yang NY, Liu XJ, Cai ZG, Lv L, Zhang L, Wu LL, Liu DG, Ren WG, Gao Y, Yu GY. Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction. Br J Ophthalmo 2014; l98:1672–1677.

28.  Wei CY, Kim Il-K, Li L, Wu LL, Gupta S. Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One 2014; 20

29.  Cong X, Zhang Y, Li J, Mei M, Ding C, Xiang RL, Zhang LW, Wang Y, Wu LL, Yu GY. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells. J Cell Sci 2015; 128:2271-2286.

30.  Mei M, Xiang RL, Cong X, Zhang Y, Li J, Yi X, Park K, Han JY, Wu LL, Yu GY. Claudin-3 is required for modulation of paracellular permeability by TNF-α through ERK1/2/slug signaling axis in submandibular gland. Cell Signal. 2015; 27(10):1915-27.

31.  Wu D, Lei H, Wang JY, Zhang CL, Feng H, Fu FY, Li L, Wu LL. CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation. J Mol Med (Berl). 2015; 93(12):1131-1329.

32.  Lei H, Wu D, Wang JY, Li L, Zhang CL, Feng H, Fu FY, Wu LL. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Basic Res Cardiol. 2015 110(4):35

33.  Xiang RL, Mei M, Su YC, Li L, Wang JY, Wu LL. Visfatin protects rat pancreatic β-cells against IFN-γ-induced apoptosis through AMPK and ERK1/2 signaling pathways. Biomed Environ Sci, 2015; 28(3):169-177.

34.  Wang C, Wen JY, Zhou Y, Li L, Cui X, Wang J, Pan L, Ye Z, Liu P,Wu LL. Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway. Int J Biochem Cell Biol. 2015; 69:173-182.

35.  Han F, Wang JY, Zheng M, Zhang CL, An YM, Li L, Wu LL. CTRP3 promotes energy production by inducing mitochondrial ROS and up-expression of PGC-1α in vascular smooth muscle cells. Experi Cell Res. 2016; 341:177-186.

36.  Zhang LW, Cong X, Zhang Y, Wei T, Su YC, Serr?o ACA, Brito Jr ART, Yu GY, Hua H, Wu LL. Interleukin-17 impairs salivary tight junction integrity in Sj?gren’s syndrome. J Dent Res. 2016; 95(7):784-792.

37.  Wei T, Ye P, Peng X, Wu LL, Yu GY.Circulating adiponectin levels in various malignancies: An updated meta-analysis of 107 studies. Oncotarget. 2016; 7(30):48671-48691.

38.  Wei T, Ye P, Peng X, Wu LL, Yu GY. Prognostic value of miR-222 in various cancers: a systematic review and meta-analysis. Clin Lab. 2016; 62:1387-1395.

39.  Zhang CL, Feng H, Li L, Wang JY, Wu D, Hao YT, Wang Z, Zhang Y, Wu LL. Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway. Biochi Biophy Acta. 2017; 1861:3085-3094.




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